Hello Medora, I can share with you one case of a woman with PCOS who had (is having) a greatly enhanced lactation experience with her 2nd baby over what happened with her first, and one changed variable in her situation was the continuous use of metformin from pregnancy through the postpartum period and lactation. During her first pregnancy (which was a shock to her), she resisted taking any kind of medication, including metformin. She has breast hypoplasia -- one very well-developed breast and one much smaller, both somewhat tubular in shape and widely spaced. She did notice breast changes during this first pregnancy. Her baby was born and transferred to the NICU, there were several barriers to breastfeeding in the early days but these were barriers that most mother-baby dyads can overcome with support and assistance (such as baby being bottle- fed, etc.). After the baby was about a week old, they started attempting to breastfeed but the mother was making no milk. Not even drops. Major attempts to relactate were begun (and this was still within the first month postpartum) but even with medications, pumping, and galactagogues, she could make only drops of milk. She was devastated. During her 2nd pregnancy, she took metformin. She also took progesterone at the end of her pregnancy (with the hope that extra progesterone might create a more precipitous drop in progesterone levels after the delivery, one hormonal factor in successful lactogenesis). This 2nd birth was with a midwife, at home, and mother and baby were not separated. There was extensive (sometimes twice daily) lactation support and baby was feeding well. As it turns out, this mother is making just over half of what her baby needs and is supplementing at the breast with donated human milk from other mothers in our community. She is also using a combined herbal tincture of fenugreek and goats' rue (with some other lactogenic herbs, I believe) and taking Domperidone. The metformin may or may not have been a significant factor in this mother's increased lactation success with her 2nd baby. Many studies show that mothers tend to make more milk after subsequent pregnancies anyway; her efforts to relactate after the first pregnancy likely influenced the readiness of her breast tissue, and the birth scnario and immediate postpartum circumstances worked to stack the deck in her favor. The fact that there has been such a significant improvement in the lactation experience for this mother tells me that there were several factors at work for her, metformin being one of them. I hope this helps you in your studies, Diana in NY *********************************************** Archives: http://community.lsoft.com/archives/LACTNET.html Mail all commands to [log in to unmask] To temporarily stop your subscription: set lactnet nomail To start it again: set lactnet mail (or [log in to unmask]) To unsubscribe: unsubscribe lactnet or ([log in to unmask]) To reach list owners: [log in to unmask]