One can only speculate why the company has not asked for approval of this medication. It is a very expensive proposition to get a drug approved by the FDA. At the time domperidone came out, there was already a gastric motility agent of a similar type already on the market (metoclopramide--Reglan), and perhaps the company did not feel the potential sales were worth the trouble. Then cisapride came on the market and then there was even less motivation for the company, especially since cisapride was supposed to be safer than metoclopramide (wrong!!). I have heard somehow, that there was one death that occurred when domperidone was given IV, though I did not know it was available IV. And that this would have made the drug harder to get through the FDA. However, not to put too fine a point on it, there isn't a drug out there that hasn't killed somebody. From my experience, though, I would say that domperidone is a lot safer than aspirin, say. Jack Newman, MD, FRCPC *********************************************** The LACTNET mailing list is powered by L-Soft's renowned LISTSERV(R) list management software together with L-Soft's LSMTP(TM) mailer for lightning fast mail delivery. For more information, go to: http://www.lsoft.com/LISTSERV-powered.html