Here is the reference. (Courtesy of a search on PubMed for "mupirocin and
candida").
They say "Mupirocin is an excellent antifungal agent".
Lisa Amir
MBBS, MMed, IBCLC in Melbourne, Australia

Int J Dermatol 1999 Aug;38(8):618-22

Perianal candidosis--a comparative study with mupirocin and nystatin.

de Wet PM, Rode H, van Dyk A, Millar AJ.

Department of Paediatric Surgery, Institute of Child Health, Red Cross War
Memorial Children's Hospital, Rondebosch, South Africa.

OBJECTIVE: To assess the efficacy and clinical outcome of 2% mupirocin in a
polyethylene glycol base and nystatin cream as treatment regimens in diaper
candidosis. DESIGN: A prospective randomized comparative study. METHODS: In
vitro. The susceptibility of 20 clinical isolates of Candida albicans to 2%
mupirocin, nystatin, and five additional antifungal agents was evaluated
using the Nathan agar-well diffusion assay. The minimum inhibitory
concentration (MIC) of mupirocin against the Candida species was determined
using a tube dilution method. In vivo. Twenty patients (mean age, 12 months;
range, 1 month to 4 years) with moderate to severe Monilia diaper dermatitis
either had mupirocin ointment or nystatin cream applied to the infected area
every 8 h or after every diaper change for a period of 7 days. Microscopic
examination of skin scrapings and mycologic and microbiological cultures
were performed before treatment and daily for 7 days, and progress was
clinically assessed. RESULTS: In vitro. Topical mupirocin produced a greater
zone of inhibition than nystatin cream, i.e. a mean of 27.2 mm (SD 1.55)
compared with a mean of 17.3 mm (SD 1.08) for nystatin cream. MIC for
mupirocin of 512 microg/mL in one case, 256 microg/mL in six cases, 200
microg/mL in 10 cases and 400 microg/mL in three cases were obtained for the
20 clinical isolates. C. albicans also displayed a universal sensitivity to
mupirocin and nystatin. In vivo. Eradication of all Candida organisms was
achieved within 2-6 days (mean, 2.6 days) in 10 patients receiving topical
mupirocin therapy with rapid healing of the excoriated wounds (mean, 4.7
days). Both Gram-positive and Gram-negative bacteria were eradicated from
the infected area within the trial period. Ten patients received topical
nystatin cream and, in each case, Candida was successfully cleared within 5
days (mean, 2.8 days). Only three wounds were clinically healed within the
trial period, however. The remaining seven wounds showed evidence of
improved, but ongoing excoriated dermatitis and a heavy growth of
polymicrobial organisms. CONCLUSIONS: Both agents eradicated Candida, the
major difference being the marked response of the diaper dermatitis to
mupirocin. Mupirocin should be applied topically 3-4 times daily or with
each diaper change and is an excellent antifungal agent.

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