SPECIAL REQUIREMENTS

Applicants should request funds for one trip in years 1 and 3 to
the
NIEHS in Research Triangle Park, North Carolina for a program
meeting.

Animal Welfare Considerations

Investigators are encouraged to consider alternative methods and
approaches in their research applications that do not require the
use
of whole animals, that use alternative species such as nonmammals
or
invertebrates, that reduce the number of animals required, and
that
incorporate refinements to procedures that will result in the
elimination of further minimization of pain and distress to
animals.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN
SUBJECT

It is the policy of the NIH that women and members of minority
groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human
subjects,
unless a clear and compelling rationale and justification is
provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public
Law
103 43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations),
which
have been in effect since 1990.  The new policy contains some
provisions that are substantially different from the 1990
policies.

All investigators proposing research involving human subjects
should
read the  NIH Guidelines for Inclusion of Women and Minorities
as
Subjects in Clinical Research,  which have been published in the
Federal Register of March 28, 1994 (FR 58 14508-14513) and
reprinted
in the NIH Guide for Grants and Contracts, Volume 23, Number 11,
March 18, 1994.

Investigators also may obtain copies of the policy from the
program
staff listed under INQUIRIES.  Program staff may also provide
additional relevant information concerning the policy.

LETTER OF INTENT

Prospective applicants are asked to submit, by December 1, 1995,
a
letter of intent that includes a descriptive title of the
proposed
research, the name, address and telephone number of the Principal
Investigator, the identities of other key personnel and
consultants,
the participating institutions, and the number and title of the
RFA
in response to which the application may be submitted.

Although a letter of intent is not required, is not binding, and
does
not enter into the review of subsequent application, the
information
that it contains is helpful in planning for the review of
applications.  It allows NIEHS staff to estimate the potential
review
work load and to avoid conflict of interest in the review.

The letter of intent is to be sent to:

Ethel B. Jackson, D.D.S.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233
111 T.W. Alexander Drive, Building 17, Room 1716
Research Triangle Park, NC  27709
Telephone:  (919) 541 7826
FAX:  (919) 541 2503