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Subject:
From:
"J. Rachael Hamlet" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Mon, 20 Jul 1998 23:11:44 -0500
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Here is a good one, but it is in a Japanese journal :-(


[Epidemiological research on incidence of atopic disease in infants and
children in relation to their nutrition in infancy]. Arerugi 1997 Apr;46(4):354-
369 [Article in Japanese]

Arita M, Mikawa H, Shirataka M, Takahashi K, Hayasawa H, Tomita M

Kansai-Denryoku Hospital.

Incidence and relative risk of atopic disease (atopic dermatitis; AD, bronchial
asthma; BA, allergic rhinitis; AR) in Japanese infants and children in relation
to their nutrition in infancy was analyzed from the data of the epidemiological
survey which was conducted for 10,000 mothers of infants and children in
1993. A total of 4,610 replies were received: 2,714 from mothers of infants
(12 months old) and 1,896 from mothers of children (2 years old). The
subjects were allocated to following 3 groups based on their nutrition during
first 3 months after birth; the breast-fed group (BF), the formula-fed group
(EF), the mixed-fed group (MF). Incidence of atopic disease in BF, FF and
MF was 23.5%, 22.2% and 21.8%, respectively and no statistical difference
could be found among these 3 groups. AD was developed 17.0%, 14.4% and
13.9%; BA was 4.4%, 8.5% and 5.2%; AR was 4.9%, 6.5% and 5.8% in BF,
FF and MF, respectively. Incidence of AD was significantly different between
BF and MF (p < 0.01). Incidence of BA was also significantly different
between BF and FF (p < 0.01). Risk of onset of BA and AR in FF was higher
(adjusted odds ratio 2.2, 95% confidence interval 1.5-3.2 and adjusted odds
ratio 1.5, 95% confidence interval 1.0-2.2, respectively) than that of BF
controlled by age and family history with Cochran-Mantel-Haenzel test.
With multiple logistic regression analysis, relative risk of the onset of BA in
FF at the age of one year was 2.1, 95% confidence interval 1.2-3.5 and at
the age of two years old was 2.5, 95% confidence interval 1.4-4.4. These
results suggest that the breast-fed have certain suppression effects on
incidence of bronchial asthma in infants and children.

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