I've posted an interesting abstract below. Seems as though what
makes something most irritating is a low pH.
My response to the debate about which is more irritating,
colostrum versus glucose water: I explain that this mother's
milk is more than just species specific for her baby, it is half
that baby's genetic material -- making it more than just mother's
milk -- making it *that baby's* milk.
Sincerely,
Andrea Eastman, MA, CCE, IBCLC
Granville, Ohio ~mailto:[log in to unmask]
***
James CF, Modell JH, Gibbs CP, Kuck EJ, Ruiz BC. Pulmonary
aspiration--effects of volume and pH in the rat. Anesth Analg
1984 Jul;63(7):665-8.
To evaluate the effect of volume of aspirates with different pHs
on mortality associated with pulmonary aspiration, hydrochloric
acid solutions were injected into the tracheas of 336
Sprague-Dawley rats. The rats were divided randomly into 33
groups, were observed for 96 hr after aspiration, and were not
resuscitated. Deaths were divided into two groups: early, less
than 30 min after aspiration, and late, greater than 4 hr after
aspiration. Late deaths, accounting for 22% of all fatalities,
occurred exclusively in animals aspirating solutions with a pH
less than 2.5. These late deaths indicated progressive lung
damage as opposed to acute cardiorespiratory failure, which early
deaths suggested. Low volume pulmonary aspirates (0.3 ml/kg) with
extremely low pH (1.0) resulted in a high mortality rate (90%).
Conversely, higher volume pulmonary aspirates (1.0-2.0 ml/kg)
with a higher pH (greater than or equal to 1.8) resulted in a low
mortality rate (14%). These data demonstrate an important
interaction between pH and volume of aspirates: even low volumes
have a high mortality rate if pH is very low, whereas if gastric
fluid is effectively buffered, then much higher volumes than
previously thought can be tolerated. This suggests that the
routine use of nonparticulate antacids may be indicated in
patients at risk from aspiration of stomach contents and should
not be withheld because of concern of increasing gastric volume.
****
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