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Subject:
From:
Nikki Lee <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 6 Jan 2011 16:28:45 -0500
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Dear Lactnet Friends:

In cows, rhGH increases rates of mastitis. What will it do in humans?

Physiol Genomics. <http://www.ncbi.nlm.nih.gov/pubmed/21205870> 2011 Jan 4.
[Epub ahead of print]
Short Term Administration of rhGH Increases Markers of Cellular
Proliferation but not Milk Protein Gene Expression in Normal Lactating
Women.

Maningat PD<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Maningat%20PD%22%5BAuthor%5D>
, Sen P <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sen%20P%22%5BAuthor%5D>
, Rijnkels M<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rijnkels%20M%22%5BAuthor%5D>
, Hadsell DL<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hadsell%20DL%22%5BAuthor%5D>
, Bray MS<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bray%20MS%22%5BAuthor%5D>
, Haymond MW<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Haymond%20MW%22%5BAuthor%5D>
.

the Rockefeller University Hospital.
Abstract

Growth hormone is one of few pharmacologic agents known to augment milk
production. We hypothesized that recombinant human GH (rhGH) increases the
expression of cell proliferation and milk protein synthesis genes.
Sequential milk and blood samples collected over four days were obtained
from five normal lactating women. Following 24h of baseline milk and blood
sampling, rhGH (0.1 mg/kg/day) was administered subcutaneously once daily
for three days. Gene expression changes were determined by microarray
studies utilizing milk fat globule RNA isolated from each milk sample.
Following rhGH administration, DNA synthesis and cell cycle genes were
induced, while no significant changes were observed in the expression of
milk synthesis genes. Expression of glycolysis and citric acid cycle genes
were increased by day 4, compared to day 1; while lipid synthesis genes
displayed a circadian-like pattern. Cell cycle gene upregulation occurred
after a lag of ~2 days, likely explaining the failure to increase milk
production after only 3 days of rhGH treatment. We conclude that rhGH
induces expression of cellular proliferation and metabolism genes, but does
not induce milk protein gene expression, as potential mechanisms for
increasing milk production and could account for the known effect of rhGH to
increase milk production following 7-10 days.

warmly,

Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com

             ***********************************************

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