Reflux is the high-fashion(drug sales) diagnosis of the times. There's 
usually little proof... Half the time the problem is more-likely gastric or 
duodenal, but since it's not appropriate to use the drugs for these 
diagnoses without evidence of an ulcer, the the reflux diagnosis allows for 
the drug sales...

Anyway, a large portion of "colic" is gastric/intestinal milk-protein 
intolerance, in mom's milk or formula. Because Zantac and such are 
histamine-2 blockers, they also will reduce part of the intestinal 
allergic/intolerance reaction and the baby may improve somewhat because of 
this, not because it's blocking some reflux, real or imagined. Real reflux 
is also often caused by milk-proteins.

Keeping the pH reduced without good reason will certainly set baby up for 
more risk of intestinal infections. Common side-effects of these drugs also 
include headache and insomnia -- at least in older children and adults -- 
they don't ask babies.

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