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From:
"Nice, Frank" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Wed, 8 Apr 1998 15:36:49 -0400
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This is the article I referred to in my last posting on disulfiram:
In the suckling rat, the low affinity hepatic aldehyde dehydrogenase component
in the newborn was different than that in the adult as assessed by kinetic
studies and by its sensitivity to disulfiram.  Nevertheless, the fact that
acetaldehyde was not detected after ethanol ingestion in suckling rats, suggests
that there is enough hepatic aldehyde dehydrogenase activity to metabolize all
the acetaldehyde generated in liver by alcohol dehydrogenase.
Suckling rats = suckling human beings in this case-who knows?
But this information does add somewhat to our overall knowledge.

Frank J. Nice, DPA, CPHP

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