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Subject:
From:
"Jon Ahrendsen, MD" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Fri, 10 Nov 1995 16:48:12 -0500
Content-Type:
text/plain
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This study did not deal with cancer it dealt with esophageal motility
disorders.  It talks about a scleroderma like condition of the esophagus.
 What follows is the download from medline that I have copied.  As I remember
this study was critized and admittedly was quite small.  IMHO the benefits of
BF still far outweight any perceived or actual risk from BF with implants.
 LLLI should be a good resource for info an this matter too.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Levine JJ, Ilowite NT
Sclerodermalike esophageal disease in children breast-fed by mothers with
silicone breast implants [see comments] [published erratum appears in JAMA
1994 Sep 14;272(10):770]
Division of Pediatric Gastroenterology, Schneider Children's Hospital, Long
Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde
Park, NY 11042.
JAMA 1994 Jan 19;271(3):213-6      Article Number:  UI94104073
ABSTRACT:
OBJECTIVE--To determine whether breast-fed children of mothers with silicone
implants are at increased risk for the development of sclerodermalike
esophageal involvement compared with children not exposed to silicone
implants. DESIGN--Case-series [corrected]. SETTING--Referral-based pediatric
gastroenterology clinic. PATIENTS--Eleven children (mean age, 6.0 years;
range, 1.5 to 13 years; six boys and five girls) referred for abdominal pain
who were born to mothers who had silicone breast implants (eight breast-fed
children and three bottle-fed) were compared with 17 patients (mean age,
10.7 years; range, 2 to 18 years; 11 boys and six girls) with abdominal pain
who were not exposed to silicone implants. METHODS--All children underwent
esophageal manometry and upper intestinal endoscopy with esophageal biopsy
and were tested for antinuclear antibody and autoantibodies to Scl-70,
centromere, ribonucleoprotein, Sm, Ro, La, and phospholipid. RESULTS--Six of
the eight breast-fed children from mothers with silicone implants had
significantly abnormal esophageal motility with nearly absent peristalsis in
the distal two thirds of the esophagus and decreased lower sphincter
pressure. Upper esophageal pressures and motility were normal. Compared with
controls, the breast-fed children had significantly decreased lower
sphincter pressure and abnormal esophageal wave propagation. These
manometric abnormalities were not seen in the three bottle-fed children.
There was no difference in the expression of autoantibodies in the
breast-fed children compared with the bottle-fed children or controls.
CONCLUSIONS--A relationship appears to exist between breast-feeding by
mothers with silicone implants and abnormal esophageal motility. Studies
evaluating larger numbers of children are needed to determine the extent of
the risk.
Comment in: JAMA 1994 Jan 19;271(3):240-1
Comment in: JAMA 1994 Sep 14;272(10):767; discussion 769-70
Comment in: JAMA 1994 Sep 14;272(10):767-8; discussion 769-70
Comment in: JAMA 1994 Sep 14;272(10):768; discussion 769-70
Comment in: JAMA 1994 Sep 14;272(10):768-9; discussion 769-70
Comment in: JAMA 1994 Sep 14;272(10):769; discussion 769-70
*
********************************************************************
*  Jon Ahrendsen, M.D. FAAFP, LLLI Medical Associate   *
*  215 13th Ave SW                                                        *
*  Clarion, Iowa 50525  USA                                            *
*  515-532-2836, FAX 532-2523, Email [log in to unmask]   *
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