Hello, everyone. Not yet back to Lactnet. Too much happening in Israel
and family crisis needs my attention. I am passing this grant info on for
anyone interested. It is very long, so skip if not relevant for
you. Judy K. in Israel
ENDOCRINE DISRUPTING CHEMICALS AND WOMEN'S HEALTH OUTCOMES

NIH GUIDE, Volume 24, Number 38, October 27, 1995

RFA:  ES-96-003

P.T. 34; K.W. 0785050, 0760025, 1007009, 0785055

National Institute of Environmental Health Sciences
Office of Research on Women's Health

Letter of Intent Receipt Date:  December 1, 1995
Application Receipt Date:  January 18, 1996

PURPOSE

Research on the health effects of chemicals and other exposures
that
are suspected to disrupt the normal activity of the endocrine
system
is a high priority of the National Institute of Environmental
Health
Sciences (NIEHS) and the Office of Research on Women's Health
(ORWH)
of the National Institutes of Health.  Exposure to these
chemicals
may have broad based systemic effects and alter reproductive,
neurologic, and/or immunologic function and may increase a human
risk
of hormonal cancers.  Accordingly, the goal of this Request for
Applications (RFA) is to encourage toxicologic, basic science,
and
epidemiologic research on the human health effects of exposure
to
chemicals that mimic, antagonize, or indirectly alter the
activity of
hormones.  Of particular interest are the health effects on
women,
since these affect both the woman herself and may affect future
offspring.  Research is encouraged to determine the endocrine
affecting potential of a variety of chemicals, understand their
biological activity, and understand the biologic consequences of
exposure during early development, the reproductive period, and
later
life.  Research on the offspring of women who have been exposed
is
also needed to understand the transgenerational effects of
exposures
to environmental chemicals that affect endocrine.

The NIEHS is the principal Federal funding agency to support
research
examining human health consequences of exposure to physical and
chemical toxicants in the environment.  Research supported by
NIEHS
spans many disciplines, including toxicology, molecular and
cellular
biology, epidemiology, and clinical research.

The Office of Research on Women's Health (ORWH) of the National
Institutes of Health (NIH) supports research on diseases,
disorders,
and conditions that affect women and ensure that research
conducted
and supported by NIH adequately addresses issues regarding
women's
health.  Research on environmental influences on women's health
has
been designated as a priority area of ORWH.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the
health
promotion and disease prevention objectives of "Healthy People
2000,"
a PHS-led national activity for setting priority areas.  This
RFA,
Endocrine Disrupting Chemicals and Women's Health Outcomes, is
related to the priority areas of environmental health and women's
health.  Potential applicants may obtain a copy of "Healthy
People
2000" (Full Report:  Stock No. 017-001-00474-0 or Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of
Documents,
Government Printing Office, Washington, DC 20402-9325 (telephone:
(202) 512-1800).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic and foreign, for-profit
and
non-profit organizations, public and private, such as
universities,
colleges, hospitals, laboratories, units of State or local
governments and eligible agencies of the Federal government.
Foreign
institutions are not eligible for First Independent Research
Support
and Transition (FIRST) (R29) awards.  Applications from minority
individuals and women are encouraged.

MECHANISM OF SUPPORT

This RFA will use the NIH individual research project grant
(R01),
and FIRST (R29) award.  Responsibility for the planning,
direction,
and execution of the proposed project will be solely that of the
applicant.  The requested costs and project period for an R01
application submitted in response to the present RFA may not
exceed
$100,000 (direct costs)/per year; R29 applications must be for
five
years.

FUNDS AVAILABLE

The total estimated funds available for the first year of support
for
the entire program is $1.5 million.  All awards will be made
directly
by NIEHS in conjunction with ORWH sponsorship.  The ORWH will
contribute funds to NIEHS to co-fund projects.  The expected
range of
number of awards is 8 to 10.

The level of support is dependent on the receipt of sufficient
number
of applications of high scientific merit.  Although this program
is
provided for within the financial plans of the NIEHS and ORWH,
awards
pursuant to this RFA are continent upon the availability of funds
for
this purpose.