I've heard this stated several times about Domperidone, that it does not 
work until after birth.

However, whilst this may true in the vast majority of cases, it is not 
true overall.  Domperidone does cause lactation, without the need for 
birth, in a small number of people.  It's called a 'side effect'.

In fact, when I reported to my GP that I was lactating, as a result of 
taking domperidone for the original use, her response was "Better you 
than a 70 year old man."  I have no idea if this was a reference to the 
fact that it could make men lactate, or a general comment about it not 
being that distressing that a healthy, non pregnant, not having given 
birth female in her late 20s, was suddenly lactating due to 
domperidone!  I'd imagine anyone just needs to check the database on its 
original use.

Likewise, had I not started lactating, I'd no doubt still be on it.  :-)

best

Morgan Gallagher

Stacy D. Kucharczk, MSN, CPNP wrote:
> Hi- I'm trying to remember if this was addressed by Dr. Hale at the LLL physician conference this summer, and I believe the response was that there was no point in using it prenatally as it won't work. Before birth, prolactin's effect on milk secretion is inhibited by high levels of progesterone (progesterone is a prolactin inhibitor). After expulsion of the placenta, progesterone levels fall and Lactogenesis II begins (source: Core Curriculum for Lactation Consultant Practice). As Domperidone increases prolactin levels (if I understand it's mechanism correctly), I can see no point in taking it prenatally. I would also want to check what pregnancy risk category to determine if it would do harm to a pregnant woman. These are just my thoughts/opinion. 
> Stacy D. Kucharczk, MSN, RN, CPNP, IBCLC

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