To Kathleen Bruce:

Kefzol(cefazolin) is a cephalosporin antibiotic.  It will pass into milk to
a limited degree and probably be destroyed in the infants GI tract.
Milk:Plasma ratio = 0.02.  Observe for a little diarrhea at most.

Dilaudid(hydromorphone) is a morphine derivative and  is about 7 times as
potent as morphine, although the dose is correspondingly less. .  Dilaudid
peak is 0.5 -1.0 hrs,   Half-life is 2-3 hrs.   Only trace amounts of
morphine ever appear in milk.   Suggest waiting a few hours after
administration.  Observe infant for sedation, constipation,  decreased
respiration.

Toradol(Ketorolac)  is a classic NSAID used frequently as a substitute for
opiate analgesics.  Following a maternal dose of 40 mg/day, the infant would
receive about 3-7 ug of ketorolac per day,   a dose clinically
insignificant(less than 0.4% of the dose).

Tom Hale

PS
And Kathleen,  this wasn't in "Briggs" !!!


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T.W. Hale, Ph.D.
Associate Professor of Pediatrics
Texas Tech University School of Medicine

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