To : Linda Shaw MD
Re : Perphenazine

Perphenazine has been studied in one patient. Infant was 1 month old, and
the mother received 24 mg/day divided in two doses.  The milk concentration
at this dose was 3.2 ug/L.  The 24 hour milk production was 510 mL; thus,
1.59 ug of perphenazine per 24 hours was transferred to the infant. This
study suggested a milk:plasma ratio of about 1.0 . The dose in the mother
was subsequently reduced to 16 mg/day...milk levels were then 2.1 ug/L.

The dose to the infant was about 0.1% of the maternal dose. No effects were
noted in the infant over 3 months of breastfeeding.

Regards
Tom Hale, PhD.

Olesen OV et.al. Perphenazine in breast milkand serum. Am. J. Psychiatry
147:1378-9, 1990.

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