Ben Lynch ND postulates a connection between tt and MTHFR polymorphisms, 
but there's nothing definitive yet. It's possible that lower activity of 
MTHFR is an issue mostly in people who don't get enough of other methyl 
donors, especially methionine, which is low in most vegetable foods 
except some seaweeds. That is certainly true of cardiac malformations, 
which are linked to inactivating MTHFR mutations (completely broken 
genes), but NOT to the common variants that just have lower activity 
(polymporphisms).

There is an X-linked gene that when mutated in critical ways is 
definitively associated with TT (in females) and TT and cleft palate (in 
males). It is variably dominant, so sometimes a female with the mutation 
is completely affected and more rarely, they have no tt at all. The gene 
is TBX22.  The mouse variant (tbx22) also causes choanal atresia 
(partial blockage of the nasal airway). Several of us here have seen 
this triad in human babies. Other studies provided evidence that there 
are other tongue tie genes that are inherited in an autosomal (not the 
sex chromosomes) dominant pattern.

I don't know anything about SSRIs and tt. Anyone else?

Catherine Watson Genna BS, IBCLC  NYC  www.cwgenna.com

On 6/13/2014 12:01 PM, Maria Dentino, RD CDN CLC wrote:
> Hi Everyone,
>
> I have tongue tie on the brain today. Wondering if anyone knows if there are any links between tongue/lip ties and MTHFR polymorphism? Or, perhaps SSRI use during pregnancy and TT?
>
> Maria Dentino, RD, CDN, CLC
> Batavia, NY
>
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