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Subject:
From:
Yanet Olivares <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 18 Jun 2011 08:06:37 -0400
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I found the two ones I have but I think I can not post them here due
to copyright issues, but here's the reference:

Indole-3-carbinol and diindolylmethane induce apoptosis of human
cervical cancer cells and in murine HPV16-transgenic preneoplastic
cervical epithelium
Da-Zhi Chen; Mei Qi; Karen J Auborn; Timothy H Carter The Journal of
Nutrition; Dec 2001; 131, 12; Research Library Core pg. 3294

Also there are more if you search EBSCO

A bit about it...

Indole-3-carbinol (I3C), a chemical found in vegetables of the
broccoli family, is thought to possess cancer preventive properties.
Indole-3-carbinol appears to work in several ways: (1) it facilitates
the conversion of estrogen to a less cancer-promoting form,1–3,6 (2)
it partially blocks the effects of estrogen on cells,4,6,30 (3) it
directly kills or inhibits cancer cells,6 and (4) it reduces levels of
free radicals, which can promote cancer by damaging DNA. 5

I3C is found in cruciferous vegetables (Brassica plants) such as
cabbage, broccoli, brussels sprouts, cauliflower, kale, kohlrabi, and
turnips. A typical Japanese diet provides the equivalent of about 112
mg of I3C daily; intake in Western diets is lower.7,8

References
1. Michnovicz JJ. Increased estrogen 2-hydroxylation in obese women
using oral indole-3-carbinol. Int J Obes
Relat Metab Disord. 1998;22:227–229.

2. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of
women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol
Biomarkers Prev. 1994;3:591–595.

3. Wong GY, Bradlow L, Sepkovic D, et al. Dose-ranging study of
indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl.
1997;28–29:111–116.

4. Yuan F, Chen DZ, Liu K, et al. Anti-estrogenic activities of
indole-3-carbinol in cervical cells: implication for
prevention of cervical cancer. Anticancer Res. 1999;19:1673–1680.

5. Arnao MB, Sanchez-Bravo J, Acosta M. Indole-3-carbinol as a
scavenger of free radicals. Biochem Mol Biol Int. 1996;39:1125–1134.

6. Bradlow HL, Sepkovic DW, Telang NT, et al. Multifunctional aspects
of the action of indole-3-carbinol as an
antitumor agent. Ann N Y Acad Sci. 1999;889:204–213.

7.HeaneyRK,FenwickGR.Naturaltoxinsandprotectivefactorsinbrassicaspecies,includingrapeseed.
Nat
Toxins. 1995;3:233–237, 242.

8. McDanell R, McLean AE, Hanley AB, et al. Chemical and biological
properties of indole glucosinolates
(glucobrassicins): a review. Food Chem Toxicol. 1988;26:59–70.

9. Wong GY, Bradlow L, Sepkovic D, et al. Dose-ranging study of
indole-3-carbinol for breast cancer
prevention. J Cell Biochem Suppl. 1997;28–29:111–116.

10. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled
trial of indole-3-carbinol in the treatment
of CIN. Gynecol Oncol. 2000;78:123–129.

11. Bradfield CA, Bjeldanes LF. Modification of carcinogen metabolism
by indolylic autolysis products ofBrassica oleraceae. Adv Exp Med
Biol. 1991;289:153–163.

12. Bjeldanes LF, Kim JY, Grose KR, et al. Aromatic hydrocarbon
responsiveness-receptor agonists generated from indole-3-carbinol in
vitro and in vivo: comparisons with
2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A.
1991;88:9543–9547.

13. Jellinck PH, Forkert PG, Riddick DS, et al. Ah receptor binding
properties of indole carbinols and induction of hepatic estradiol
hydroxylation. Biochem Pharmacol. 1993;45:1129–1136.

14. Arnao MB, Sanchez-Bravo J, Acosta M. Indole-3-carbinol as a
scavenger of free radicals. Biochem Mol Biol Int. 1996;39:1125–1134.

15. Kelloff GJ, Boone CW, Crowell JA, et al. New agents for cancer
chemoprevention. J Cell Biochem Suppl. 1996;26:1–28.

16. Broadbent TA, Broadbent HS. The chemistry and pharmacology of
indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole.
[Part II]. Curr Med Chem. 1998;5:469–491.

17. Background information. Indole-3-carbinol (I3C). 700-06-1, June
28, 2000. National Institute of Environmental Health Sciences web
site. Available at:
http://ntp-server.niehs.nih.gov/htdocs/Chem_Background/ExecSumm/Indolecarbinoll.
Accessed September 19, 2000.

18.HeaneyRK,FenwickGR.Naturaltoxinsandprotectivefactorsinbrassicaspecies,includingrapeseed.
Nat Toxins. 1995;3:233–237, 242.

19. McDanell R, McLean AE, Hanley AB, et al. Chemical and biological
properties of indole glucosinolates (glucobrassicins): a review. Food
Chem Toxicol. 1988;26:59–70.

20. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled
trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol.
2000;78:123–129.

21. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of
the use of indole-3-carbinol for recurrent respiratory papillomatosis.
Otolaryngol Head Neck Surg. 1998;118:810–815.

22. Shertzer HG, Berger ML, Tabor MW. Intervention in free radical
mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol.
Biochem Pharmacol. 1988;37:333–338.

23. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled
trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol.
2000;78:123–129.

24. Background information. Indole-3-carbinol (I3C). 700-06-1, June
28, 2000. National Institute of Environmental Health Sciences web
site. Available at:
http://ntp-server.niehs.nih.gov/htdocs/Chem_Background/ExecSumm/Indolecarbinoll.
Accessed September 19, 2000.

25. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled
trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol.
2000;78:123–129.

26. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of
the use of indole-3-carbinol for recurrent respiratory papillomatosis.
Otolaryngol Head Neck Surg. 1998;118:810–815.

27. Wong GY, Bradlow L, Sepkovic D, et al. Dose-ranging study of
indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl.
1997;28–29:111–116.

28. Dashwood RH. Indole-3-carbinol: anticarcinogen or tumor promoter
in brassica vegetables? Chem Biol Interact. 1998;110:1–5.

29. Bailey GS, Hendricks JD, Shelton DW, et al. Enhancement of
carcinogenesis by the natural anticarcinogen indole-3-carbinol. J Natl
Cancer Inst. 1987;78:931–934.

30. Meng Q, Yuan F, Goldberg ID, et al. Indole-3-carbinol is a
negative regulator of estrogen receptor-alpha signaling in human tumor
cells. J Nutr. 2000;130:2927-293l .

31. Chinni SR, Sarkar FH. Akt inactivation is a key event in
indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res.
2002;8:1228-1236.

32. Hong C, Firestone GL, Bjeldanes LF. Bcl-2 family-mediated
apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast
cancer cells. Biochem Pharmacol. 2002 Mar 15;63(6):1085-1097.

33. Rahman KM, Sarkar FH. Steroid hormone mimics: molecular mechanisms
of cell growth and apoptosis in normal and malignant mammary
epithelial cells. J Steroid Biochem Mol Biol. 2002;80:191-201.

34. Auborn KJ. Therapy for recurrent respiratory papillomatosis.
Antivir Ther. 2002;7:1-9.

35. Wilker C, Johnson L, Safe S. Effects of developmental exposure to
indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on
reproductive potential of male rat offspring. Toxicol Appl Pharmacol .
1996; 141:68-75.

36. Stoner G, Casto B, Ralston S, et al. Development of a multi-organ
rat model for evaluating chemopreventive agents: efficacy of
indole-3-carbinol. Carcinogenesis. 2002;23:265-272.

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