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Subject:
From:
Chris Hafner-Eaton <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Wed, 14 Feb 2001 11:19:50 -0800
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I'm posting yet another article on soy and it's possible negative effects
because I received numerous emails (some queries, some positive, and some a
bit hostile regarding my suggestion that soy was not an appropriate
substitute for human milk).  There are many more, but I'll contain myself.
For those interested in this topic, I highly encourage that you go to the
original articles.  They are full of interesting info.

Maximum Relevance:Phytoestrogens in soy-based infant foods: concentrations,
daily intake, and possible biological effects.
Proc Soc Exp Biol Med 1998 Mar;217(3):247-53   (ISSN: 0037-9727)
Irvine CH; Fitzpatrick MG; Alexander SL [Find other articles with these
Authors]
Animal and Veterinary Sciences Group, Lincoln University, Canterbury, New
Zealand. [log in to unmask]
Exposure to estrogenic compounds may pose a developmental hazard to infants.
Soy products, which contain the phytoestrogens, genistein and daidzein, are
becoming increasingly popular as infant foods. To begin to evaluate the
potential of the phytoestrogens in these products to affect infants, we
measured total genistein and daidzein contents of commercially available
soy-based infant formulas, infant cereals, dinners, and rusks. We also
assayed phytoestrogens in dairy-based formulas and in breast milk from
omnivorous or vegetarian mothers. In most cases, the glucoside forms of the
phytoestrogens were hydrolyzed before separation by HPLC. Mean (+/-SEM)
total genistein and daidzein contents in four soy infant formulas were
87+/-3 and 49+/-2 microg/g, respectively. The phytoestrogen content of
cereals varied with brand, with genistein ranging from 3-287 microg/g and
daidzein from 2-276 microg/g. By contrast, no phytoestrogens were detected
in dairy-based infant formulas or in human breast milk, irrespective of the
mother's diet (detection limit = 0.05 microg/ml). When fed according to the
manufacturer's instruction, soy formulas provide the infant with a daily
dose rate of total isoflavones (i.e., genistein + daidzein) of approximately
3 mg/kg body weight, which is maintained at a fairly constant level between
0-4 months of age. 

Supplementing the diet of 4-month-old infants with a single daily serving of
cereal can increase their isoflavone intake by over 25%, depending on the
brand chosen.*** This rate of isoflavone intake is much greater than that
shown in adult humans to alter reproductive hormones. Since the available
evidence suggests that infants can digest and absorb dietary phytoestrogens
in active forms and since neonates are generally more susceptible than
adults to perturbations of the sex steroid milieu, we suggest that it would
be highly desirable to study the effects of soy isoflavones on
steroid-dependent developmental processes in human babies.***

--Chris Hafner-Eaton, PhD, MPH, CHES, IBCLC    [log in to unmask]
€€€INFANT CUISINE AND MOTHER CARE: LACTATION CONSULTING & PERINATAL CARE€€€

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