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Subject:
Paroxetine(Paxil)
From:
Tom Hale <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 20 Feb 1997 16:16:43 -0600
Content-Type:
text/plain
Parts/Attachments:
text/plain (14 lines) 
Colleagues:

A short letter to the editor last month reviews the breast milk level of
paroxetine(Paxil) in one patient at steady state.  Source = Spigset et.al.
J.Clin Psy. 57:1, p39, 1996

The concentration of paroxetine in milk, obtained 4 hours after the dose(20
mg/day), was 23 nmol/L (7.6 ug/L).  This is a milk:plasma ratio of about 0.09.
 Daily dose to infant would be approximately 1.14 ug/Kg body weight or about
0.34% of the maternal dose,  exceptionally low.

Regards
Tom Hale

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