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Subject:
From:
"David A. Green" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Fri, 18 Dec 1998 17:28:03 EST
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Just in case you have a doc say something about breast-feeding not compatible
with the Rotavirus vaccine, I wanted to let you know the facts.
Although breast-feeding HAS BEEN demonstrated to decrease the immunogenicity
of SINGLE doses of Rotavirus vaccine, NO overall effect has been noted on
immune response or efficacy after administration of 3 DOSES of Rotavirus
vaccine.
Pichichero ME.  Effect of breast-feeding on oral rhesus rotavirus vaccine
seroconversion:  a metaanalysis.  J Infect Dis. 1990:162:753-755.
Rennels MB, Wasserman SS, Glass RI, Deane VA, US Rotavirus Vaccine Efficacy
Group.  Comparison of immunogenicity and efficacy of rehesus rotavirus
reassortant vaccines in breastfed and nonbreastfed children.  Pediatrics.
1995;96:1132-1136.

Andrew MD FAAP
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