To      : Judy Eastburn
Re      : Zyprexa (Olanzaprine )

Olanzaprine is a brand new,  potent neuroleptic drug primarily used for
treating schizophrenia.  It is similar in action to clozapine.  It has a number
of typical side effects including extrapyramidal symptoms, occassional elevated
liver enzymes, and other typical side effects characteristic of these families
of drugs.

There is no data that I can find on its transfer into breastmilk in humans but
it is secreted in rodent milk.   But I would assume some of it does transfer in
human milk simply due to its lipophilicity and huge volume of
distribution(1,148 Liters).

Unfortunately,  it has a 31( 21-54) hour half-life and requires glucoronidation
prior to urinary excretion, which as you know is not very functional in newborn
livers (it would probably tend to build up over time in the infant).

I do not think this would be a suitable drug to use in a breastfeeding mother
at this time.  By the way, the concomitant use of carbamazepine may increase
Zyprexa clearance.

Regards
Tom Hale, Ph.D.