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Subject:	Topiramate (Topamax)
From:	"Nice, Frank (NIH/NINDS)" <[log in to unmask]>
Reply To:	Lactation Information and Discussion <[log in to unmask]>
Date:	Mon, 22 Sep 2003 07:34:54 -0400
Content-Type:	text/plain
Parts/Attachments:	text/plain (21 lines)

Milk:plasma ratio was 0.86 for five mothers taking up to 400mg per day.
Breastfed infants had very low concentrations. No adverse effects were
observed.
Ohman I, Vitols S, Luef G, Soderfeldt B, Thomson T. Topiramate kinetics
during delivery, lactation, and in the neonate: preliminary observations.
Epilepsia 2002, 43: 1157-60.

Frank J. Nice, DPA, CPHP

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