Propolis Derivative May be Used to Treat Parkinson's Disease 

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New findings from France, Turkey and Germany describe advances in
neurology…

Study 3: Caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced
neurotoxicity.

According to a recently published study from Germany, "Parkinson's
disease (PD) is a neurodegenerative disorder characterized by
progressive loss of dopaminergic (DA) neurons of the substantia nigra
pars compacta…

"Caffeic acid phenethyl ester (CAPE), an antioxidant flavanoid, has
antiviral, anti-inflammatory, antioxidant, and immunomodulatory
properties. Recent studies have shown that CAPE has also a
neuroprotective effects in ischemia and low potassium-induced neuronal
apoptotic models," the authors said…

The researchers concluded, "Since a mitochondrial insult is a major
cause for the degeneration of nigral neurons in PD, we hypothesize that
propolis derivatives, in particular CAPE, may have a neuroprotective
effect on those cells and may be a promising drug candidate to be taken
into in vivo models of PD."…

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