Nosema resistance

Honey bee colonies (Apis mellifera) have been selected for low level of Nosema in Denmark over decades
and Nosema is now rarely found in bee colonies from these breeding lines.  The differences
in the response of the innate immune system between the selected and unselected lineage were
strongest at day six post infection. In particular genes of the Toll pathway were up-regulated in the
selected strain, probably is the main immune pathway involved in N. ceranae infection response. After
decades of selective breeding for Nosema tolerance in the Danish strain, it appears these bees are tolerant
to N. ceranae infections. 

Journal of Invertebrate Pathology 109 (2012) 297–302

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