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Subject:	Re: A transmissible RNA pathway in honey bees
From:	Pete B <[log in to unmask]>
Reply To:	Informed Discussion of Beekeeping Issues and Bee Biology <[log in to unmask]>
Date:	Tue, 28 Aug 2018 23:10:45 -0400
Content-Type:	text/plain
Parts/Attachments:	text/plain (17 lines)

> Is it possible that off-target effects are what's hampering Monsanto's RNAi efforts at varroa control?

I would guess that's part of it. Maybe Randy has more info on that. I don't.

> Meaning that the different jellies would produce different epigenetic effects correct?

That seems to be the implication. To me, it makes more sense than the older theory that merely the quantity of food would effect the changes we see. New paper states

> Our results demonstrate a key role for chromatin modifications in the establishment and maintenance of caste-specific transcriptional programs in the honey bee.

Marek Wojciechowski, et al. 2018. Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development.  http://www.genome.org/cgi/doi/10.1101/gr.236497.118

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