> The results of our research clearly showed an increase in the frequency of chromosome aberrations provoked by fumagillin, especially at the dose of 20 mg/kg bw, which significantly influenced the amplification of certain chromosome regions on one of the chromosomes of the first pair of autosomes in a certain number of the animals tested. 
 
> Our results concerning the increased frequencies of chromosome aberrations (poliploidy, aneuploidy, gaps, acentrics and insertions) induced by fumagillin lead to the conclusion that fumagillin residues in food may have genotoxic effects that could increase the risk for chromosome aberrations and cancer.

> Moreover, beekeepers, who are occupationally exposed to fumagillin, may also be at genotoxic risk. There is an urgent necessity for their compulsory education concerning consumers' safety. Similar caution should be taken with patients treated with fumagillin against microsporidia.

Arch. Biol. Sci., Belgrade, 62 (1), 47-55, 2010	DOI:10.2298/ABS1001047S
FUMAGILLIN-INDUCED CHROMOSOME ABERRATIONS IN MOUSE BONE-MARROW CELLS
Z. STANIMIROVIC
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