"Natural Product" is a very specific term used by the Organic chemistry, and pharmaceutical communities.  It refers to any "organic" (def. containing C,H,N mainly) compound that is isolated from a living organism.  Oxytetracycline is a natural product as it is extracted from an actinomycete soil bacterium and no futher chemical modification is done.  Biaxin (Clarithromycin) is not a natural product as it is derrived from Erythromycin A (isolated from saccaraspora erythrea) by chemically modifying the "6-hydoxyl" to a "6-methoxyl" group.  

Fumagillin is absolutely a natural product.  These "secondary metabolites" are, as is the case of Erythromycin, thought to be produced to protect the organism from competing bioflora.  It is speculate that because S. erythrea only produced Erythromycins when it is it's reproductive sporulation phase and weak, that the natural product protects it's "turf" from other opportunistic soil bacteria.  Mark

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