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Subject:	Re: Large-scale field application of RNA interference (RNAi) technology to reduce impact of Israeli Acute Paralysis Virus...
From:	Peter L Borst <[log in to unmask]>
Reply To:	Informed Discussion of Beekeeping Issues and Bee Biology <[log in to unmask]>
Date:	Thu, 28 Oct 2010 07:38:58 -0400
Content-Type:	text/plain
Parts/Attachments:	text/plain (17 lines)

RE: RNAi

> Better understanding of mechanisms that lead to toxicity and biosafety issues are essential before RNAi can become a practical therapeutic. Important aspects related to toxicity that need consideration include immune activation and off-target effects.

> Both siRNA and shRNA can induce off-target effects by fortuitous base pairing with unintended mRNAs resulting in suppression of important cellular components 

> Because miRNAs are essential for the regulation of cell growth, differentiation and apoptosis, if the machinery for miRNA biogenesis is diverted to handle exogenous siRNA or shRNA, then a dearth of miRNAs can potentially manifest as toxicity

Expert Opinion on Biological Therapy: RNA interference-based therapeutics
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