https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329244/

Propolis and its constituents against cardiovascular risk factors including
obesity, hypertension, atherosclerosis, diabetes, and dyslipidemia: A
comprehensive review
Abstract

Cardiovascular diseases (CVDs) are some of the major causes of death
worldwide. The modern lifestyle elevates the risk of CVDs. CVDs have
several risk factors such as obesity, dyslipidemia, atherosclerosis,
hypertension, and diabetes. Using herbal and natural products plays a
pivotal role in the treatment of different diseases such as CVDs, diabetes,
and metabolic syndrome. Propolis, a natural resinous mixture, is made by
honey bees. Its main components are phenolics and terpenoid compounds such
as caffeic acid phenethyl ester, chrysin, and quercetin. In this review,
multiple studies regarding the pharmacological impacts of propolis and its
constituents with their related mechanisms of action against mentioned CVD
risk factors have been discussed in detail. Here, we used electronic
databases or search engines such as Scopus, Web of Science, Pubmed, and
Google Scholar without time limitations. The primary components of propolis
are phenolics and terpenoid compounds such as caffeic acid phenethyl ester,
chrysin and quercetin. Propolis and its constituents have been found to
exhibit anti-obesity, anti-hypertension, anti-dyslipidemic,
anti-atherosclerosis, and anti-diabetic effects. The vast majority of
studies discussed in this review demonstrate that propolis and its
constituents could have therapeutic effects against mentioned CVD risk
factors via several mechanisms such as antioxidant, anti-inflammatory,
reducing adipogenesis, HMG-CoA reductase inhibitory effect, inhibition of
the ACE, increasing insulin secretion, NO level, etc.

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