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Fri, 14 Jun 2019 21:29:22 -0400 |
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News from the front:
The Mendelian rules of random assortment dictate that a given gene has a 50% chance of being transmitted to progeny through sexual reproduction, though CRISPR-based gene drives breach this barrier by increasing the inheritance limit towards 100% (i.e., super-Mendelian inheritance). This rate allows rapid gene transmission and is ushering in an era of active genetics, making gene drives potentially applicable in everything from basic research to ecological engineering, including for managing both insect-borne diseases and invasive pest species as well as in ecosystem restoration. For example, gene drives have allowed ~100% transmission of antimalarial or infertility genes within Anopheles mosquito populations in the laboratory, enabling efficient population modification or suppression, respectively. However, multiple concerns and challenges surround the use of gene drives in both laboratory and ecological settings.
Small-molecule control of super-Mendelian inheritance in gene drives
bioRxiv preprint first posted online Jun. 14, 2019
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