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Date: | Fri, 26 Oct 2012 18:39:41 -0400 |
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oh scientific data!! if you look a the graph from that paper it looks like Fumagillin-B is quite stable at 4 degrees C, but at 30 C you can expect about 5% decomposition over 24hrs or 0.25% per hour, at 40 C you can expect to see about 10% loss over 24hrs or about 0.5% per hour. If you do the back of the envelope calculation that for every 10 degrees a reaction rates double, at 50 C you will likely have decomposition at 20% or more per day (around 1% per hour). So if you warm up your syrup to 50C you will probably lose less than 5% to decomposition if you heat it less than an hour, however you can't really heat solutions uniformly to temperature rapidly, so usually you'll have a significant temperature differential where the container and solution near the heating source will be significantly hotter perhaps 20-40 degrees hotter, so if you do heat it, do it in a water bath not a flame or electric heating element.
Consider if your crystalizing solution has been stored at room temp (22-25 C) you already have lost about 10% per week of storage. Mark
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