Honey May Supplement Anti-Typhoid Drugs
Manuka Honey and Its Antimicrobial Potential Against Multi-Drug
Resistant Strains of Typhoidal Salmonellae
Prof. Abdul Hannan, Muhammad Barkaat, Sidrah Saleem, Muhammad Usman,
Waseem Ahmed Gilani, Department of Microbiology, University of Health
Sciences, Lahore, Pakistan
http://apitherapy.blogspot.com/2009/03/honey-may-supplement-anti-typhoid-drugs.html
[Presented at 7th German Apitherapy, Apipuncture and Bee Products
Congress, Expo and Workshops with International Participation in Passau,
Germany, March 26-31, 2009.]
Problem: Typhoid Fever
• A global as well as local problem
• 16-33 million cases occur worldwide
• With over 500,000 to 600,000 deaths
• 93% cases occur only in Asia
• Endemic in Pakistan
Chloramphenicol was introduced in 1948 for the treatment of typhoid
fever, which dramatically reduced the incidence of typhoid fever and
converted a distressing, and often lethal disease into a readily
manageable condition.
However, this optimism did no last very long and resistance to
chloramphenicol emerged in 1950. By the 1972, widespread resistance to
this drug reported, which posed a serious threat to health community.
Ampicillin and co-trimoxazole replaced chloramphenicol and became the
treatment of choice at that time. However, in the late 1980s and early
1990s, S. typhi strains also developed simultaneous plasmid mediated
resistance to all three first line antibiotics.
These strains disseminated globally and were designated MDR.
The situation has further aggravated with the recent emergence of
fluoroquinolone resistance as well as ceftriaxone resistance.
Consequently, it had become very difficult and expensive for health
community to treat typhoid fever, especially in developing countries
like Pakistan, where the burden of typhoid fever is already quite high.
Honey has been used as a healing agent throughout the human history
besides its widespread usage as a popular food (White, 1966)…
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