Thanks Adony for your post after our discussion on Sunday. I always had
trouble comparing the results of these two papers. Time has come to
revisit the fumagillin application methods for various management systems
and climatic conditions.
Harrison was wondering why dusting is good for tylosin and Oxy Tet
application why not fumagillin. Available published data have not shown a
better mean for applying dusting that will produce good efficacy. I might
suggest that too many factors could be involved i.e. the type of pathogen,
the mode of action of fumagillin, fumagillin half life, etc. And the
most important factor is brood diseases vs adult diseases. The effects of
these variables should be considered in any study. The most interesting
studies about fumagillin are coming from the medical sciences. Recent
studies showed that Fumagillin suppresses HIV-1 infection of macrophages
through the inhibition of Vpr activity.
Time has come to revisit this issue and I am sure that there are many
studies are underway to address these issues.
Medhat
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