Tuesday, June 24, 2008
Propolis Reduces Chicken Mortality from Newcastle Disease 
 Antiviral Activity of Propolis Against Some Avian Viruses
A. G. Hegazi1, F. K. Abd El Hady and A.A. Faraghli, Departments of
Zoonotic Diseases and Chemistry of Natural Products, National Research
Center, Dokki, Giza, Egypt. Animal Health Research Institute, Dokki,
Giza, Egypt. E- mail: [log in to unmask] and
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[Presented at APIMEDICA and APIQUALITY 2008 in Rome.]

Three Egyptian propolis samples were collected from Dakahlia, Ismailia
and Sharkia provinces. The antiviral activity of propolis samples was
investigated against some avian viruses as infectious bursal disease
virus (IBDV), reovirus (RV), infectious bronchitis virus (IBV),
larngotracheitis virus (LTV) and Newcastle disease virus (NDV). All
propolis samples showed antiviral activity. It was obvious that Dakahlia
propolis showed the highest antiviral activity against IB virus and LTV.
While Ismailia propolis had the highest antiviral activity against IBDV
and RV. On the other hand, Sharkia propolis showed the highest antiviral
activity against NDV.

The influence of administration of Egyptian propolis on chicken infected
with virulent Newcastle disease virus was investigated. The mortality
rate of chickens was reduced in NDV infected group which was
subsequently treated with propolis. Infection with vvNDV induced a
significant reduction of chicken body weight. Propolis induced a
significant increase in antibody titer against NDV in the infected group
which was subsequently treated with propolis.


The chemical composition of propolis samples were investigated by GC/MS,
103 compounds were identified, 20 being new for propolis Dakahlia
propolis was a typical poplar propolis but it contained two new caffeate
esters and two new triterpenoids. Ismailia propolis was characterized by
the presence of new triterpenic acid methyl esters and it did not
contain any aromatic acids, esters and flavonoids.Sharkia propolis was
characterized by the presence of caffeate esters only, some di- and
triterpenoids.

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