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Subject: (ARM) Four year follow-up of neonates having epidurals
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Here is another study for the interest of the list and to post anywhere:

Hollenbeck AR, Grout LA, Smith RF, Scanlon JW.  Neonates prenatally exposed
to anesthetics: Four-year follow-up.  Child Psychiatry and Human Development
1986; 17(1):66-70.

Abstract:  This brief report provides the four year follow-up on infants
prenatally exposed to anesthetics.  Fourteen of 39 infants examined at birth
were available for intelligence testing at age four.  Results indicate that
Peabody Picture Vocabulary IQ scores are correlated with visual preference
testing at birth in infants exposed to prenatal anesthetics.  The mean IQ's
of these infants also differed from mean IQ's of unexposed infants at four
years.   These preliminary data are suggestive of prenatal anesthetic effects
that are persistent and that early infant visual screening may be predictive
of later IQ.

Blair VW, Hollenbeck Ar, Smith RF, Scanlon JW.  [Neonatal preference for
visual patterns: Modifications by prenatal anesthetic exposure.
Developmental Medicine and Child Neurology 1984; 26:476-483.] studied 9
infants who had been exposed to an anesthetic prenatally with 30 unexposed
infants, testing for visual pattern preferences.  The exposed infants looked
at stimuli longer and had different preferences for some pairs of patterns.

These same authors documented substantial behavioral effects in rats
prenatally exposed to lidocaine and mepivacaine.

Looking time at birth was correlated with PPVT Scaled IQ scores at four years
(r = -.91, p < .01) for the exposed groupwhile there was no correlation for
the unexposed group.  After covarying out initial looking differences, there
was a significant mean difference in PPVT IQ scores between exposure groups
(t = 1.91, d.f. = 12, p <.05, one-tailed).  Approximately one standard
deviation separated the means of the exposed group (M = 91.33, s.d. = 14.56)
and the unexposed group (M = 107.75, s.d. = 19.94).

This small study follow-up provides data consistent at four years with the
results following birth.   The infant group exposed to anesthetic agents
continued to show visual performance differences at four years.... What seems
remarkable is that even with such a small sample size, a group difference is
still detected.



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