This sort of stuff is maddening: <She had previously treated her symptoms of irritability with evening primrose oil. She found this to be very successful for herself but has been told by the local health food store to not take epo while breastfeeding. Is there any information pro or con on epo while nursing?> EPO is an excellent source of essential fatty acids and their more complex metabolites (GLA) - regarded as "safe when used appropriately" by the Botanical Safety Handbook. EPO is derived from Oenothera biennis seeds and is an excellent source of GLA ( gamma linoleic acid). "Heroic" doses ( i.e. overdose) of essential fatty acids have been known to provoke gall bladder attacks. I wonder about but have absolutely no solid evidence to back up an idea that repeated plugged ducts/mastitis conditions may be helped by adding food sources of essential fatty acid derivatives, such as EPO, fish oils, etc. Anyone observe this? Sheila Humphrey BSc RN IBCLC