To : Erin Re : Levaquin (levofloxacin) Levofloxacin is just another of the fluoroquinolone antibiotics. We have no data on its transfer into human milk. I am presently suggesting that BFing mothers who must have a fluoroquinoline, use Trovafloxacin (Trovan). I have enclosed the monograph from my book below. The levels published by the manufacturer show low milk levels. Lastly, as for radioactive substances, please check my WEB page and get the NRC table on breastfeeding. This table is quite good, and every breastfeeding mother who needs a radioactive substance should "hand this printout" to the radiologist. At least this way, the radiologist might learn something. Regards Tom Hale Ph.D. ------------------------- Trovafloxacin Mesylate Trade: Trovan, Alatrofloxacin Can/Aus/UK: Uses: Antibiotic AAP: Not reviewed Trovafloxacin mesylate is a synthetic broad-spectrum antibiotic for oral use. The IV formula is called alatrofloxacin mesylate which is metabolized to trovafloxacin in vivo. Trovafloxacin is a fluoroquinolone antibiotic similar to ciprofloxacin, norfloxacin and others. Trovafloxacin was found in measurable but low concentrations in breast milk of three breastfeeding mothers. Following an IV dose of 300 mg trovafloxacin equivalent, and repeated oral 200 mg doses of trovafloxacin mg daily, breast milk levels averaged 0.8 mg/L and ranged from 0.3 to 2.1 mg per liter of milk. This would average less than 0.4% of the maternal dose. Alternatives: Norfloxacin, Ofloxacin Pregnancy Risk Category: C Adult Concerns: Dizziness, nausea, headache, vomiting, diarrhea have been reported. Pediatric Concerns: None reported via milk. Only small amounts are secreted in milk. Drug Interactions: Antacids, Morphine, Sucralfate, and iron significantly reduce oral absorption. AHL = 12,2 hours M/P = PHL = PB = 76% PK = 1,2 hours Oral = 88% MW = 512 pKa = Vd = 1.3 References: 1. Pharmaceutical Manufacturer's package insert, 1998.