To : Nola Re : ACE inhibitors The ACE inhibitors are considered Pregnancy Risk Category D in pregnant women, not only because they may be teratogenic, but because when used in the second and third trimesters, and the infant is born with ACE inhibitors on board, the infant has a high and dangerous risk of being hypotensive and shocky. Hypotension, neonatal anemia, hyperkalemia, neonatal skull hypoplasia, anuria, oligohydramnios, intrauterine growth retardation, prematurity, and renal failure have been reported in fetuses and neonates exposed to ACE inhibitors. Most of these effects apparently do not occur with exposure in the first trimester, but their incidence increases during the second and third trimesters. So I would be really hesitant to ever recommend a pregnant women use an ACE inhibitor. Regards Tom Hale, Ph.D.