I have been reading with interest the question concerning the effects of hormone replacement therapy on breastfeeding and will throw a twist into the pot in the hopes that this will bring about some interesting discussions. Turner Syndrome is a chromosomal disorder affecting approximately 1:2000 live- born phenotypic females which means that it estimated at approximately 50,000 to 75,000 children and woman in the US. Part of the treatment may include Growth Hormone therapy and Estrogen therapy, the latter which may begin as early as 12 years of age and will continue for life under medical supervision with the general recommendation being that they be treated with cyclical estrogen and progestin. Approximately 1-3% of these women are able to conceive on their own, others will need to consider IVF and/or adoption. My question is . . . how will this prolong use of estrogen therapy affect the milk supply? Will they need to use Reglan (or other) in order to maintain a milk supply? Alesha says "her milk still had not come in by the fourth postpartum day" considering this was this mom's first pregnancy I thought it was not uncommon since the milk can mature in 3-5 days in first time moms. When was this mom started with instructions to begin pumping? Since her babies are being supplemented with formula then her breasts are not receiving any stimulation and therefore continuing with their normal function under the endocrine control. There is no mention in this situation of wether or not the babies ever went to breast, assuming that they did not, it sounds like a mishandling of breastfeeding accompanied with the fear of a previous medical condition. Well Jack, what do you think? See ya, Yvonne **************************** Yvonne C. Bannister, IBCLC Private Practice/Baby's BestFeeding "A mother holds her baby . . . . who holds her breast and gets the best!"