Date: Fri, 1 Dec 1995 12:59:07 -0600 From: "Dr. Tom Hale" <[log in to unmask]> Subject: Re: Fluconazole vs Nizoral RE: Fluconazole I would like to add support to Dr. Eglash's comments on using Fluconazole(Diflucan). I fully concur with her comments. We have a long history using fluconazole in a pediatric population. The FDA has even designated the product as safe down to 1 day of age. I agree that it is horribly expensive(perhaps I should say Outrageously expensive), but its safety profile in pediatric patients is exemplary. I do not think that nizoral is a suitable alternative. Nizoral requires an acid stomach to be absorbed. With the constant presence of milk, an acid environment suitable for absorption of nizoral is unlikely, and could conceivably markedly reduce the absorption of nizoral in an infant(we don't know for sure) . If offers no real advantages over fluconazole. Tom Hale