>>Had been treated with nystantin pill X 2wks., then nystantin liquid for mother and baby x2 wks.<< Diana, I hope that all involved in this particular treatment decision realized how worthless it was for the mother's part. Nystatin works for babies because their yeast is on exposed tissues from mouth through to anus. Nystatin is not orally absorbed, and doesn't need to be to reach baby's affected areas. However, for a mom with ductal thrush..... nystatin never gets into her system, it just passes through the digestive tract, so it never reaches her breast. Not much help! :-) The diflucan was the only treatment choice that had the potential to reach the ductal yeast. I prefer to see the nipples continue to be treated topically, as well as the baby's mouth (and bottom, if affected), while mom is on the diflucan. Without concurrent therapy, you cannot guarantee that it won't be passed back as soon as the diflucan is finished! As far as mom's continued red nipples are concerned.... it may be residual yeast on the surface. I would add the topical as I mentioned above and see if that makes a difference. If not, then she might consider visiting a dermatologist; after this much time, she may also have developed a secondary infection, or may have localized inflammation that might respond to a topical steroid. On the issue of baby popping on and off..... if baby's thrush is no longer being treated, it could be coming back, and it does make their mouth uncomfortable; that is one other possibility here. -Lisa Marasco, LLLL, IBCLC