Dear Jay: Some of my psychiatrist pals have had good luck with Prozac but also Zoloff (which from what I understand is more specific). The tricyclic antidepressants are the ones that are frequently recommended for breastfeeding mothers. You might consider contacting the national office of Depression After Delivery to see if they have any more current information. From what I understand, they are planning some articles in their next newsletter on this topic. (215) 295-3994. I don't know how serious this woman's depression is, but she might also consider looking into some of the alternatives. High levels of complex carbs int he diet, moderate exercise. Both of these have been found to influence serotonin levels and decrease depression. Does she have enough help and support? Does she have a birth experience that was traumatic or difficult? Have other physical causes for her depression been explored--severe disruption in sleep, anemia, hypothyroidism, allergies? These might be some other avenues she wishes to explore. I hope this helps. Kathy Kendall-Tackett Ph.D. LLLL Henniker New Hampshire