Date: Wed, 27 Sep 1995 01:10:47 -0400 From: "Jon Ahrendsen, MD" <[log in to unmask]> Subject: BF and Zoloft(sertraline) I found this citation in NURSES DRUG ALERT VOL XIX AUG 95 NO8 page 63. It discusses a case report from Journal of Clinical Psychiatry1995;56(june):243-245. It discusses a 28 yr old woman who took nortriptyline and sertraline(Zoloft) for depression throughout pregancy and BF. Attempts to stop the drugs during preg, were unsuccessful. They measure the antidepressant in BM, maternal serum and infant serum at 3 weeks and 7 weeks of age. BM samples were taken before the single HS dose of med and at each feeding for the next 24 hours. Serum levels were check 12 hours after drug was taken. The levels in BM peaked at samples 5 and 9 hours after dosing. Levels of both drugs were undectable in the infants serum. The child had normal growth and development. The level of dection in the assays of the infant were .5ng/ml for sertraline and 10ng/ml for nortriptyline, so that means that if there was any drug in the infant it was below the levels noted above. The study was funded by Pfizer. Jon Ahrendsen, M.D. - ----------------------------------------------------------------- Kathleen B. Bruce, BSN, IBCLC, LLL Leader Co-Owner Lactnet, LLLOL, Corgi-L E-mail lists LACTNET WWW site: http://www.mcs.com/~auerbach/lactation.html -----------------------------------------------------------------