I too have seen a couple of mothers who never produce milk regardless of effective L-O techniques, pumping, galatagogues, etc, etc, etc. One mother was older (late 30's) with history of estrogen problems and hormone use to get pregnant. The other was in her 20's, no indicators that might tip us off that she would have problems with milk production. Both mothers also declined to have endocrine workups done. So much disappointment that the breastfeeding wasn't working, I guess. For research and other reasons it would be nice to know. But I understand their state of mind also. If they did agree to a endocrine workup would we (or anyone) know what we were looking for or would it be the foundation for future research to help target potential problems? Denise Parker