Hi Lisa and Fiona, I have on occasion opened blisters in my office with a sterile needle. Like other parts of the body, I usually don't recommend patients do this themselves, as medicolegally, if they get an infection from taking this advice over the phone, I am at risk. Of course, I hate practicing medicine with such a concern , but that is truly life in the US for MDs. But the other thing about blisters is that they are a symptom of something else, as they occur from the nipple rubbing on the upper palate, so there is a suck issue here. Therefore, the mom/baby dyad should be seen. When I have opened blisters, it has been to decrease pain, and it does somewhat. I also have cultured the fluid, but have never gotten a positive culture. The blisters sometimes recur, depending on whether the underlying issue has resolved.-Anne Eglash MD