I don't recommend the PDR as a primary drug resource for 3 very good reasons. 1) as mentioned before, it is a paid advertisment given to most dr. free (by some drug company that has their new med in it.) 2) It is not all inclusive (not all drugs are in it, only the ones the drug companies want the dr's to have there hands on.) 3) It gives no more information than the package insert on the bottle (the data stated there is already a couple (2-5) years old before it ever gets to the pharmacy.) Food for thought: Almost no drugs (I can not think of any) are tested in newborns, then it makes sense why all new meds have the cover your butt statement of weigh benifits against risks (even when there are not ANY known risks) in nursing couples. Most drugs used in newborns & premies started out as non labeled uses & were proven through research and use to be "safe". However, we need to remember that all drugs are chemicals. And that we are using a side effect of a chemical to alter a body system. Therefore whenever we alter a body system, there are potential risks (it may be 1 in a million) but it is still a risk----Has anyone read the full monograph (package insert on ASA, lately- I have) makes me wonder how such a "dangerous" drug ever got on the market. I do NOT routinely recomend the use of diflucan-otc lotrimin-otc monistat, until all other "proven" methods have been explored. We need to remember that diflucan is given to compromised NICU babies on a regular basis in much higher doses (with minimal side effects), than the usual resistant thrush case baby would be exposed to. So the likelyhood of adverse side effects are minimized. The overuse of any medication when it is not truely indicated, leads to resistance (is this not where we started this dicussion.) Sorry that this reply is so long, but I just finished a shift at my pharmacy & I am a little long winded on the over explaination. Anne Norton-Krawciw, RPh, IBCLC Breastfeeding Specialists Inc [log in to unmask]