Thanks Catherine for your great explanation of the prolactin receptors and how they work. If I understood correctly, the receptors are on the cells that synthesize milk, the alveoli? So, when breast involution occurs, eithe after weaning, or as baby gets to be a toddler and doesn't drink all that much at breast, do alveoli dissapear, along with their receptors? Is a multipara starting out with the same nuber of receptors as a primip in the first phase of BF? What about if mom is tandem nursing? Would the amount of involution that has occured effect how many receptors are left? And finally, how would this effect how soon mature milk "comes in", and how soon mom gets to the third stage of BM production. And maybe the occurence of painful afterpains, or not, depends on how much BF was going on with the toddler, and thus, how much active alveoli are left or how many prolactin receptors. Actually, oxytocin receptors seem more relavent to the issue of after pains. Do you know where these are and how many??? Just really curious Dalia Abrams *********************************************** The LACTNET mailing list is powered by L-Soft's renowned LISTSERV(R) list management software together with L-Soft's LSMTP(TM) mailer for lightning fast mail delivery. For more information, go to: http://www.lsoft.com/LISTSERV-powered.html