To : Lori Re : Taxol We do not know how much, if any, Taxol enters milk. However, it does have a rather long half-life of 52 hours, and its volume of distribution is huge, suggesting that it might be stored in peripheral compartments and released over many days of time, thus it could produce low and sustained milk levels. On the other hand, its molecular weight is large and its plasma levels rather low, which would suggest its ability to enter milk would be low. So I cannot really suggest that it is safe to breastfeed after using this drug. If the mom wanted to pump and dump for 10 days, then it would probably be safe, but I'm not really sure of this. Drugs with huge Volumes of Distribution tend to leach out of tissues for long periods. We just don't have any set answer for this situation. Does the benefit of breastfeeding outweight the risk of this dangerous drug. Its questionable. Sorry. Tom Hale, PH.D. *********************************************** The LACTNET mailing list is powered by L-Soft's renowned LISTSERV(R) list management software together with L-Soft's LSMTP(TM) mailer for lightning fast mail delivery. For more information, go to: http://www.lsoft.com/LISTSERV-powered.html