The increase in weight was FAT mass, not lean muscle or organ mass, and the 
 intervention was short-lived The Valentine trial (AKA P. Meier's  NICU) 
(JPGN 1994) lasted only 2 weeks.
 
We want LEAN, long premies with big brains, not short, fat infants who will 
 develop obesity, hypertension, insulin-resistance and heart disease in  
adulthood, like we used to produce.
 
Other longer trials have shown no difference
Dayanikli  P et al. PAS 2004, San Francisco, Abstr  # 2526 & #2194.
Other studies suggest concern regarding human  milk post discharge:
¢RCT of preterm infants fed fortified human milk or preterm formula until  
term CA
 
¢At  term 3 groups:
—Nutrient-enriched  formula without extra energy
—Standard  formula
—Unfortified  human milk
¢Results  at 6 months corrected age:
—No  differences in growth or body size
—Enriched  formula group had less fat mass
—Standard  formula group had higher fat mass
—Human  milk group had lower lean mass and higher fat mass

Amesz  EM et al. Optimal growth and lower fat mass in preterm infants fed a 
 protein-enriched postdischarge  formula. J Pediatr Gastroenterol Nutr  
2010; 50(2):200-207
Nancy
Nancy E.  Wight MD, IBCLC, FABM, FAAP
Neonatologist
Sharp Mary Birch Hospital for  Women and Newborns
Medical Director, Sharp HealthCare Lactation  Services
San Diego, CA 
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