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Subject:
From:
Catherine Fetherston <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Wed, 25 Feb 2004 10:21:22 +0800
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On 24/2/04 9:50 PM, "Automatic digest processor"
<[log in to unmask]> wrote:

> I recently talked to a mom whose physician recommended early weaning (5
> weeks ago) due to "an enzyme in her milk caused by her
> hypogammaglobulinemia".


People with hypogammaglobulinaemia are very vulnerable to infection, they
have very low levels of immunoglobulins and cannot respond adequately to
infectious insults (particularly encapsulated bacteria and viruses) This
results  in recurrent and severe occurrences of infections such as
pneumonia, sinusitis, osteomyeltitis, dermatitis and septicaemia.

Bruton's tyrosine kinase (Btk) is required for human and mouse B cell
development. Btk deficiency causes X-linked agammaglobulinaemia (XLA) in
humans and X-linked immunodeficiency in mice. I'm assuming this is the
enzyme to which the doctor refers.

I cannot see why this would lead to advice to wean. Certainly her breastmilk
will be immunoglobulin deficient (and it would be interesting to see a
profile of her breastmilk immune components). However there are many other
antimicrobial components in breastmilk so it is still important for the
infant protection wise. I cant imagine why breastfeeding would be
deleterious to the mother with this condition- I would be interested to hear
his explanation.

Cathy Fetherston
Western Australia

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