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Subject:
From:
Judy Ritchie <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 2 Dec 2000 11:33:03 -0800
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Another reason to get the newly pregnant women eligible on
WIC and for docs and midwives to give advice on total nutrition.

Fetal Undernutrition May Affect Liver Function

WESTPORT, CT (Reuters Health) Nov 29 - Fetal undernutrition
may permanently alter liver function, according to a report
in the October issue of the British Journal of Haematology.

Dr. Tessa J. Roseboom, of the Academic Medical Centre Amsterdam,
in the Netherlands, and colleagues examined the medical records
of 725 people who were born around the time of the Dutch famine
of 1944 to 1945. All subjects were interviewed regarding their
medical history, lifestyle and use of medication.  Clinical
measurements were taken of height, weight, and fibrinogen and
factor VII plasma concentrations.

The researchers found that those "exposed to famine in early
gestation were more obese, and had higher total cholesterol
concentrations and higher LDL/HDL cholesterol ratios," while
those "exposed in late and mid gestation seemed to have
somewhat lower total cholesterol concentrations."

Subjects undernourished in early gestation "had slightly but
significantly lower factor VII concentrations and slightly but
non-significantly higher fibrinogen concentrations than people
who were not exposed to famine during gestation," the authors
write. This "suggests that liver function may be affected by
undernutrition in early gestation."

"Our findings show for the first time that coronary heart
disease and its risk factors are affected by maternal nutrition
during gestation. By optimizing maternal diet from the beginning
of the pregnancy, we might be able to prevent coronary heart
disease in future generations," Dr. Roseboom told Reuters Health.

"Our group is planning further investigations to hopefully
unravel the mechanisms underlying these long-term effects, " she added.

Br J Haematol 2000;111:112-117.

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